师资队伍

袁佳俐，博士，副教授，1990年11月生，江苏南通人。2019年毕业于南京医科大学公共卫生学院劳动卫生与环境卫生学专业。2019.09-2022.04在美国路易斯维尔大学公共卫生与信息科学学院从事博士后工作，研究方向为职业暴露及金属纳米颗粒物的毒性机制研究。现在就职于徐州医科大学公共卫生学院劳环卫教研室，承担《职业卫生与职业医学》的教学工作。研究方向为矽肺病发病机制和金属纳米粒子的健康效应研究，主持校级优秀人才启动基金一项、江苏省高校自然科学研究面上项目一项、国家青年自然科学基金一项，以第一或通讯作者在Particle and fibre toxicology、Environmental pollution、Nanotoxicology等杂志发表SCI论文多篇。

研究方向：

1.尘肺病致病的人群易感性和分子机制研究

2.大气颗粒物和金属纳米颗粒物的健康效应研究

近五年主持或参加的项目/课题：

1.国家自然科学基金委员会，青年项目，2024-01至2026-12，30万元 （在研，主持）

2.江苏省高等学校基础科学（自然科学）研究，面上项目，2023-07至2025-07，3万元 （在研，主持）

3.徐州医科大学优秀人才启动基金, 2023-01至2025-12, 20万元（在研，主持）

4.国家自然科学基金委员会,面上项目, 2019-01-01至2022-12-31, 58万元（资助期满，参与）

近五年代表性论著：

1.Yuan J⁺,Mo Y⁺, Zhang Y, Zhang Y, Zhang Q: Nickel nanoparticles induce autophagy and apoptosis via HIF-1α/mTOR signaling in human bronchial epithelial cells.Environmental pollution (Barking, Essex : 1987)2023, 329:121670.

2.Yuan J⁺, Wang T⁺, Wang L⁺, Li P, Shen H, Mo Y, Zhang Q, Ni C: Transcriptome-wide association study identifies PSMB9 as a susceptibility gene for coal workers' pneumoconiosis.Environmental toxicology2022, 37(8):2103-2114.

3.Yuan J⁺, Mo Y⁺, Zhang Y, Zhang Y, Zhang Q: Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1α/HDAC3 pathway.Nanotoxicology2022, 16(6-8):695-712.

4.Yuan J⁺, Mo L⁺, Mo Y, Zhang Y, Zhang Y, Zhang Q:A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells.Toxicology2022, 477:153271.

5.Yuan J⁺, Zhang Y⁺, Zhang Y, Mo Y, Zhang Q: Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes.Particle and fibre toxicology2021, 18(1):13.

6.Yuan J⁺, Li P⁺, Pan H, Xu Q, Xu T, Li Y, Wei D, Mo Y, Zhang Q, Chen Jet al: miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1.Ecotoxicology and environmental safety2021, 220:112372.

7. Zhang Y, Zhang Z, Mo Y, Zhang Y,Yuan J, Zhang Q: MMP-3 mediates copper oxide nanoparticle-induced pulmonary inflammation and fibrosis.Journal of nanobiotechnology2024, 22(1):428.

8. Yu T⁺, Zhang Y⁺,Yuan J⁺, Zhang Y, Li J, Huang Z: Cholesterol mediates the effects of single and multiple environmental phenols in urine on obesity.Lipids in health and disease2024, 23(1):126.

9. Huang Z, Chen X, Wang Y,Yuan J, Li J, Hang W, Meng H: SLC7A11 inhibits ferroptosis and downregulates PD-L1 levels in lung adenocarcinoma.Frontiers in immunology2024, 15:1372215.

10. Zhang Y, Mo Y, Zhang Y,Yuan J, Zhang Q: MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts.Particle and fibre toxicology2023, 20(1):22.

11. Mo Y, Mo L, Zhang Y, Zhang Y,Yuan J, Zhang Q: High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages.Particle and fibre toxicology2023, 20(1):41.

12. Zhang Y, Mo Y,Yuan J, Zhang Y, Mo L, Zhang Q: MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells.Nanotoxicology2021, 15(10):1380-1402.

13. Mo Y, Zhang Y, Zhang Y,Yuan J, Mo L, Zhang Q: Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway.Journal of nanobiotechnology2021, 19(1):370.

14. Li Y, Sun W, Pan H,Yuan J, Xu Q, Xu T, Li P, Cheng D, Liu Y, Ni C: LncRNA-PVT1 activates lung fibroblasts via miR-497-5p and is facilitated by FOXM1.Ecotoxicology and environmental safety2021, 213:112030.