简介:毕皓然,女,中国农工民主党党员,2019年毕业于哈尔滨医科大学,获流行病与卫生统计学博士学位。现任徐州医科大学公共卫生学院卫生统计学教研室副教授、硕士生导师。主要研究方向为肿瘤分子流行病学,重点涉及基因组学、表观遗传组学、转录组学等多组学高通量测序数据分析,肿瘤易感性和预后的生物标志物,基因与环境交互作用,及环境污染物的健康效应研究等。承担《卫生统计学》、《医学统计学》等研究生和本科生课程的教学工作,指导大学生创新创业项目2项。
邮箱:bihaoran@xzhmu.edu.cn
代表性论文:
1、Li Jianan,Bi Haoran. Molecular mechanisms of atrazine toxicity on H19-7 hippocampal neurons revealed by integrated miRNA and mRNA "omics". Ecotoxicol Environ Saf, 2023, 253: 114681. (中科院一区,通讯作者)
2、Haoran Bi, Zhang Yanyan, Qin Pei et al. Association of Chinese Visceral Adiposity Index and Its Dynamic Change with Risk of Carotid Plaque in a Large Cohort in China. J Am Heart Assoc, 2022, 11(1):e022633. (中科院二区,第一作者)
3、Li Jianan,Bi Haoran.Integrated strategy of network pharmacology and in vitro screening to identify mechanism of diazinon-induced hippocampal neurotoxicity. Neurotoxicology, 2022, 92: 122-130. (中科院二区,通讯作者)
4、Li Jianan,Bi Haoran. Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach. Ann Gen Psychiatry. 2024, 31;23(1):8. (中科院三区,通讯作者)
5、Li Jianan, Qi Ling, Chen Yuxin, Lv Haoming,Bi Haoran.Bioinformatics analysis of the potential mechanisms of Alzheimer's disease induced by exposure to combined triazine herbicides. Ann Hum Biol. 2023, 50(1):442-451. (中科院四区,通讯作者)
6、Li Shirui, Gao Zhihui, Zhong Meihan, Yu Zhujun, Li Jianan,Bi Haoran. Chinese University Students' Awareness and Acceptance of the COVID-19 Vaccine: A Cross-Sectional Study. Risk Manag Healthc Policy. 2022, 15:845-864. (中科院四区,通讯作者)
7、Li Jianan,Bi Haoran.Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine. Toxicol Mech Methods, 2022, 32: 259-267. (中科院四区,通讯作者)
8、Li Jianan,Bi Haoran. The effect and mechanism of cypermethrin-induced hippocampal neurotoxicity as determined by network pharmacology analysis and experimental validation. Bioengineered, 2021, 12: 9279-9289. (中科院四区,通讯作者)
9、Tian Tian#,Haoran Bi#, Ding Zhang, et al. Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk. Cancer Med. 2021, 10(14):4964-4976. (中科院二区,并列一作)
10、Haoran Bi,Yupeng Liu, Rui Pu, et al. CHST7 Gene Methylation and Sex-Specific Effects on Colorectal Cancer Risk. Dig Dis Sci. 2019, 64(8):2158-2166. (中科院四区,第一作者)
11、Haoran Bi, Yupeng Liu, Tian Tian, et al. A Propensity Score-adjusted Analysis of the Effects of Ubiquitin E3 Ligase Copy Number Variation in Peripheral Blood Leukocytes on Colorectal Cancer Risk. J Cancer. 2019, 10(14):3291-3302. (中科院三区,第一作者)
12、Haoran Bi, Tian Tian, Lin Zhu, et al. Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer. Sci Rep. 2016, 15;6:29869. (中科院二区,第一作者)
科研课题:
1、 国家自然科学基金-青年基金项目(2022),30万,主持,在研。
2、 徐州医科大学优秀人才科研基金(2019),30万,主持,结题。
3、 徐州医科大学博士后启动项目(2021),6万,主持,在研。
4、 徐州市科技计划项目(青年人才项目)(2022),6万,主持,在研。
5、 江苏省卫生健康委医学科研项目(2021),2万,主持,在研。
6、 徐州医科大学国家自然科学基金孵育项目(2021),5万,主持,结题。